Sleep Wake Cycle Disturbance May Be Predictor for Alzheimer Disease

Circadian Rest-Activity Pattern Changes in Aging and Preclinical Alzheimer Disease Erik S. Musiek, MD, PhD1,2; Meghana Bhimasani, BS1; Margaret A. Zangrilli1; et al John C. Morris, MD1,2; David M. Holtzman, MD1,2; Yo-El S. Ju, MD1 Author Affiliations JAMA Neurol. Published online January 29, 2018. doi:10.1001/jamaneurol.2017.4719 … Disturbances of the rest-activity rhythm are present in preclinical Alzheimer disease, even after accounting for effects of aging and sex, … Read more