Sleep Wake Cycle Disturbance May Be Predictor for Alzheimer Disease

Sleep Wake Cycle Disturbance May Be Predictor for Alzheimer Disease

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Circadian Rest-Activity Pattern Changes in Aging and Preclinical Alzheimer Disease

Erik S. Musiek, MD, PhD^1,2; Meghana Bhimasani, BS¹; Margaret A. Zangrilli¹; et al John C. Morris, MD^1,2; David M. Holtzman, MD^1,2; Yo-El S. Ju, MD¹

Author Affiliations

JAMA Neurol. Published online January 29, 2018. doi:10.1001/jamaneurol.2017.4719

… Disturbances of the rest-activity rhythm are present in preclinical Alzheimer disease, even after accounting for effects of aging and sex, demonstrating that circadian dysfunction occurs very early in the course of Alzheimer disease and precedes cognitive symptom onset…

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